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Article

Analysis of the structure and function of the transcriptional coregulator HOP.

Biochemistry - 5 Sept 2006

Kook Hyun, Yung Wendy W, Simpson Raina J, Kee Hae Jin, Shin Sera, Lowry Jason A, Loughlin Fionna E, Yin Zhan, Epstein Jonathan A, Mackay Joel P

Abstract excerpt

Homeodomain-only protein (HOP) is an 8-kDa transcriptional corepressor that is essential for the normal development of the mammalian heart. Previous studies have shown that HOP, which consists entirely of a putative homeodomain, acts downstream of Nkx2.5 and associates with the serum response factor (SRF), repressing transcription from SRF-responsive genes. HOP is also able to recruit histone deacetylase (HDAC)...

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PMID: 16939210
DOI: 10.1021/bi060641s

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SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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