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Article

A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling.

Genes & development - 1 Aug 2003

Ariyoshi Mariko, Schwabe John W R

Abstract excerpt

Spen proteins regulate the expression of key transcriptional effectors in diverse signaling pathways. They are large proteins characterized by N-terminal RNA-binding motifs and a highly conserved C-terminal SPOC domain. The specific biological role of the SPOC domain (Spen paralog and ortholog C-terminal domain), and hence, the common function of Spen proteins, has been unclear to date. The Spen protein, SHARP...

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Source

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Identifiers

PMID: 12897056
DOI: 10.1101/gad.266203
PMCID: PMC196244

Genes

HDAC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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