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Article

Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.

Science signaling - 5 Nov 2019

Jarrett Sanchez M, Seegar Tom C M, Andrews Mark, Adelmant Guillaume, Marto Jarrod A, Aster Jon C, Blacklow Stephen C

Abstract excerpt

Canonical Notch signaling relies on regulated proteolysis of the receptor Notch to generate a nuclear effector that induces the transcription of Notch-responsive genes. In higher organisms, one Notch-responsive gene that is activated in many different cell types encodes the Notch-regulated ankyrin repeat protein (NRARP), which acts as a negative feedback regulator of Notch responses. Here, we showed that NRARP...

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Identifiers

PMID: 31690634
DOI: 10.1126/scisignal.aay2369
PMCID: PMC7212804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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