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Article

SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.

The EMBO journal - 15 Oct 2002

Oswald Franz, Kostezka Ulrike, Astrahantseff Kathy, Bourteele Soizic, Dillinger Karin, Zechner Ulrich, Ludwig Leopold, Wilda Monika, Hameister Horst, Knöchel Walter, Liptay Susanne, Schmid Roland M

Abstract excerpt

Notch proteins are the receptors for an evolutionarily highly conserved signalling pathway that regulates numerous cell fate decisions during development. Signal transduction involves the presenilin-dependent intracellular processing of Notch and nuclear translocation of the intracellular domain...

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Source

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Identifiers

PMID: 12374742
DOI: 10.1093/emboj/cdf549
PMCID: PMC129081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12374742-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.PMID 12374742Read ↗

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.Semantic proximity Read ↗

A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling.Semantic proximity Read ↗

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.Semantic proximity Read ↗

Structural and functional studies of the RBPJ-SHARP complex reveal conserved corepressor binding siteSemantic proximity Read ↗

Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1.Semantic proximity Read ↗

SHARPIN is a key regulator of immune and inflammatory responses.Semantic proximity Read ↗

Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.Semantic proximity Read ↗

OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor.Semantic proximity Read ↗

Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice.Semantic proximity Read ↗

Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development.Semantic proximity Read ↗

Notch -- a goldilocks signaling pathway in disease and cancer therapy.Semantic proximity Read ↗

Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.Semantic proximity Read ↗

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