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Article

The C-terminal tail of CSNAP attenuates the CSN complex.

Life science alliance - 1 Oct 2023

Füzesi-Levi Maria G, Ben-Nissan Gili, Listov Dina, Fridmann Sirkis Yael, Hayouka Zvi, Fleishman Sarel, Sharon Michal

Abstract excerpt

Protein degradation is one of the essential mechanisms that enables reshaping of the proteome landscape in response to various stimuli. The largest E3 ubiquitin ligase family that targets proteins to degradation by catalyzing ubiquitination is the cullin-RING ligases (CRLs). Many of the proteins that are regulated by CRLs are central to tumorigenesis and tumor progression, and dysregulation of the CRL family is...

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PMID: 37460146
DOI: 10.26508/lsa.202201634
PMCID: PMC10355216

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