Article

The structure, binding, and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3

2022-02-09

Abstract excerpt

The highly conserved Notch pathway transmits signals between neighboring cells to elicit distinct downstream transcriptional programs. In given contexts, Notch is a major regulator of cell fate specification, proliferation, and apoptosis, such that aberrant Notch signaling leads to a pleiotropy of human diseases, including developmental disorders and cancers. The canonical pathway signals through the transcription...

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Literature Corpus work: bdc5b8d8-43ac-5b97-b1f7-6732da78c4f4
DOI: 10.1101/2022.02.09.479311

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