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Article

Clonal Hematopoiesis and Its Impact on Human Health.

Annual review of medicine - 27 Jan 2023

Ahmad Herra, Jahn Nikolaus, Jaiswal Siddhartha

Abstract excerpt

Aging is associated with increased mutational burden in every tissue studied. Occasionally, fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process occurs in several tissues but has been best studied in blood. Clonal hematopoiesis is associated with an increased risk of blood cancers, such as acute myeloid leukemia, which result if additional cooperating mutations occur....

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Identifiers

PMID: 36450282
DOI: 10.1146/annurev-med-042921-112347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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