Article
The longitudinal dynamics and natural history of clonal haematopoiesis.
Nature - 1 Jun 2022
Fabre Margarete A, de Almeida José Guilherme, Fiorillo Edoardo, Mitchell Emily, Damaskou Aristi, Rak Justyna, Orrù Valeria, Marongiu Michele, Chapman Michael Spencer, Vijayabaskar M S, Baxter Joanna, Hardy Claire, Abascal Federico, Williams Nicholas, Nangalia Jyoti, Martincorena Iñigo, Campbell Peter J, McKinney Eoin F, Cucca Francesco, Gerstung Moritz, Vassiliou George S
Abstract excerpt
Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1-4. The understanding of how and when clonal haematopoiesis develops, the factors that govern its behaviour, how it interacts with ageing and how these variables relate to malignant progression remains limited5,6. Here we track...
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