Article

Spatial Chromatin Architecture Alteration by Structural Variations in Human Genomes at Population Scale

2018-09-14

Abstract excerpt

This genome-wide study is focused on the impact of structural variants identified in individuals from 26 human populations onto three-dimensional structures of their genomes. We assess the tendency of structural variants to accumulate in spatially interacting genomic segments and design a high-resolution computational algorithm to model the 3D conformational changes resulted by structural variations. We show that...

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Literature Corpus work: ee29d818-c92e-5248-b3b9-7263e2bf2ec2
DOI: 10.1101/266981

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