Article

Global reference mapping and dynamics of human transcription factor footprints

2020-02-01

Abstract excerpt

Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits 1 , yet it remains challenging to distinguish variants that impact regulatory function 2 . Genomic DNase I footprinting enables quantitative, nucleotide-resolution delineation of sites of transcription f...

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Literature Corpus work: 00eefbef-e236-5722-a33e-e3717b3f8886
DOI: 10.1101/2020.01.31.927798

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