Article
Population Variation and Genetic Control of Modular Chromatin Architecture in Humans.
Cell - 27 Aug 2015
Waszak Sebastian M, Delaneau Olivier, Gschwind Andreas R, Kilpinen Helena, Raghav Sunil K, Witwicki Robert M, Orioli Andrea, Wiederkehr Michael, Panousis Nikolaos I, Yurovsky Alisa, Romano-Palumbo Luciana, Planchon Alexandra, Bielser Deborah, Padioleau Ismael, Udin Gilles, Thurnheer Sarah, Hacker David, Hernandez Nouria, Reymond Alexandre, Deplancke Bart, Dermitzakis Emmanouil T
Abstract excerpt
Chromatin state variation at gene regulatory elements is abundant across individuals, yet we understand little about the genetic basis of this variability. Here, we profiled several histone modifications, the transcription factor (TF) PU.1, RNA polymerase II, and gene expression in lymphoblastoid cell lines from 47 whole-genome sequenced individuals. We observed that distinct cis-regulatory elements exhibit...
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