Article

The N-terminal domain of the human mitochondrial helicase Twinkle has DNA binding activity crucial for supporting processive DNA synthesis by Polymerase γ

2022-11-10

Abstract excerpt

<h4>ABSTRACT</h4> Twinkle is the ring-shaped replicative helicase within the human mitochondria with high homology to bacteriophage T7 gp4 helicase-primase. Unlike many orthologs of Twinkle, the N-terminal domain (NTD) of human Twinkle has lost its primase activity through evolutionarily acquired mutations. The NTD has demonstrated no observed activity thus far, hence its role has remained unclear. In this study,...

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Literature Corpus work: 7dd38d6b-4b69-57f7-bb6e-1a22964d801d
DOI: 10.1101/2022.11.10.516034

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