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Article

Structural basis for the coiled-coil architecture of human CtIP.

Open biology - 1 Jun 2021

Morton C R, Rzechorzek N J, Maman J D, Kuramochi M, Sekiguchi H, Rambo R, Sasaki Y C, Davies O R, Pellegrini L

Abstract excerpt

The DNA repair factor CtIP has a critical function in double-strand break (DSB) repair by homologous recombination, promoting the assembly of the repair apparatus at DNA ends and participating in DNA-end resection. However, the molecular mechanisms of CtIP function in DSB repair remain unclear. Here, we present an atomic model for the three-dimensional architecture of human CtIP, derived from a multi-disciplinary...

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Identifiers

PMID: 34129781
DOI: 10.1098/rsob.210060
PMCID: PMC8205527

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