Article

Characterization of human XPD helicase activity with Single Molecule Magnetic Tweezers

2023-02-07

Abstract excerpt

<h4>ABSTRACT</h4> XPD helicase is a DNA unwinding enzyme involved in multiple cellular processes. As part of TFIIH, XPD opens a repair bubble in DNA for access by proteins in the nucleotide excision repair pathway. XPD uses the energy from ATP hydrolysis to translocate in the 5’ to 3’ direction on one strand of duplex DNA, displacing the opposite strand in the process. We used magnetic tweezers assays to measure...

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Literature Corpus work: 5c252427-7614-517a-a8be-10401fad6ec8
DOI: 10.1101/2023.02.07.527508

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