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Systematic analysis of the molecular and biophysical properties of key DNA damage response factors

21 Jun 2023

Abstract excerpt

Repair of DNA double strand breaks (DSBs) is integral to preserving genomic integrity. Therefore, defining the mechanisms underlying DSB repair will enhance our understanding of how defects in these pathways contribute to human disease and could lead to the discovery of new approaches for therapeutic intervention. Here, we established a panel of HaloTagged DNA damage response factors in U2OS cells which enables...

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PMID: 37341699
DOI: 10.7554/elife.87086

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