Article

Structural and Dynamic Basis of DNA Capture and Translocation by Mitochondrial Twinkle Helicase

2022-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Twinkle is the sole helicase responsible for mitochondrial DNA replication. Twinkle can selfload onto and unwind mitochondrial DNA. Nearly 60 mutations on Twinkle have been linked to human mitochondrial diseases. Using cryo-electron microscopy (cryo-EM) and High-speed atomic force microscope (HS-AFM), we obtained the atomic-resolution structure of a vertebrate Twinkle homolog with DNA and captur...

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Literature Corpus work: c2afbbd3-e8e9-5ea1-baea-3fd794c86cd2
DOI: 10.1101/2022.08.11.503323

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