Article

The PALB2 DNA-binding domain is an intrinsically disordered recombinase

2023-09-18

Abstract excerpt

<title>Abstract</title> <p>The Partner and Localizer of BRCA2 (PALB2) tumor suppressor is a scaffold protein that links BRCA1 with BRCA2 to initiate homologous recombination (HR). PALB2 interaction with DNA strongly enhances HR efficiency. The PALB2 DNA-binding domain (PALB2-DBD) supports DNA strand exchange, a complex multistep reaction supported by only a few protein families such as RecA-like recombinases or R...

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Literature Corpus work: 6fb4aebe-eb80-5378-a275-4cad653fd29e
DOI: 10.21203/rs.3.rs-3235465/v1

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