Article

A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortex

2017-09-01

Abstract excerpt

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by the progressive accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles in the neocortex. Recent studies have implicated a role for regulatory genomic variation in AD progression, finding widespread evidence for altered DNA methylation associated with neuropathology. To date, however, no study has systematically examined o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: edca6e6f-a778-5bd2-a471-d0cb142148ff
DOI: 10.1101/183541

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortexDOI 10.1101/183541Read

A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortexSemantic proximity Read

Cell type-specific histone acetylation profiling of Alzheimer’s Disease subjects and integration with geneticsSemantic proximity Read

Histone H3 Lysine 4 and 27 Trimethylation Landscape of Human Alzheimer’s DiseaseSemantic proximity Read

Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with geneticsSemantic proximity Read

Epigenomic Aberrations of Histone Methylation in Prefrontal Cortex of Humans with Mild Cognitive Impairment and Alzheimer’s DiseaseSemantic proximity Read

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brainsSemantic proximity Read

The Role of H3K9 Acetylation and Gene Expression in Different Brain Regions of Alzheimer’s Disease PatientsSemantic proximity Read

The three-dimensional landscape of chromatin accessibility in Alzheimer’s diseaseSemantic proximity Read

Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brainSemantic proximity Read

CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disordersSemantic proximity Read

Histone acetylation in an Alzheimer’s disease cell model promotes homeostatic amyloid-reducing pathwaysSemantic proximity Read

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s diseaseSemantic proximity Read