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Histone acetylation in an Alzheimer’s disease cell model promotes homeostatic amyloid-reducing pathways

2 Jan 2024

Abstract excerpt

Abstract Alzheimer’s Disease (AD) is a disorder characterized by cognitive decline, neurodegeneration, and accumulation of amyloid plaques and tau neurofibrillary tangles in the brain. Dysregulation of epigenetic histone modifications may lead to expression of transcriptional programs that play a role either in protecting against disease genesis or in worsening of disease pathology. One such histone modification,...

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PMID: 38167174
DOI: 10.1186/s40478-023-01696-6

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