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Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease

2018-09-29

Abstract excerpt

<h4>Background</h4> Late-onset Alzheimer’s disease (AD) is a complex age-related neurodegenerative disorder that likely involves epigenetic factors. To better understand the epigenetic state associated with AD represented as variation in DNA methylation (DNAm), we surveyed 420,852 DNAm sites from neurotypical controls (N=49) and late-onset AD patients (N=24) across four brain regions (hippocampus, entorhinal cort...

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Literature Corpus work
230aaa49-420b-56db-8add-78ac1c191496
DOI
10.1101/430603
Open publication

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Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s diseaseDOI 10.1101/430603
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