Article

CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders

2021-09-06

Abstract excerpt

Acetylation of histone H3 lysine 27 (H3K27ac) has emerged as an informative disease-associated epigenetic mark. However, cell type-specific contributions to epigenetic dysregulation in disease are unclear as studies have often used bulk brain tissue. Therefore, methods for the deconvolution of bulk H3K27ac profiles are critical. Here we developed the Cell type-specific Histone Acetylation Score (CHAS), a computati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e39126a-6372-59de-a386-4716c63b2222
DOI: 10.1101/2021.09.06.459142

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disordersDOI 10.1101/2021.09.06.459142Read

Cell type-specific histone acetylation profiling of Alzheimer’s Disease subjects and integration with geneticsSemantic proximity Read

Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with geneticsSemantic proximity Read

A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortexSemantic proximity Read

Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome.Semantic proximity Read

Systematic assessment of the biological impact of cellular deconvolution on downstream analyses of disease transcriptomesSemantic proximity Read

Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human BrainSemantic proximity Read

Single-cell epigenomic identification of inherited risk loci in Alzheimer’s and Parkinson’s diseaseSemantic proximity Read

Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structureSemantic proximity Read

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.Semantic proximity Read

Cell type-specific associations with Alzheimer’s Disease conserved across racial and ethnic groupsSemantic proximity Read

A single cell brain atlas in human Alzheimer’s diseaseSemantic proximity Read

A landscape of the genetic and cellular heterogeneity in Alzheimer diseaseSemantic proximity Read