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Article

A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex.

Nature neuroscience - 1 Nov 2018

Marzi Sarah J, Leung Szi Kay, Ribarska Teodora, Hannon Eilis, Smith Adam R, Pishva Ehsan, Poschmann Jeremie, Moore Karen, Troakes Claire, Al-Sarraj Safa, Beck Stephan, Newman Stuart, Lunnon Katie, Schalkwyk Leonard C, Mill Jonathan

Abstract excerpt

We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal cortex samples from Alzheimer's disease (AD) cases and matched controls using chromatin immunoprecipitation and highly parallel sequencing. We observed widespread acetylomic variation associated with AD neuropathology, identifying 4,162 differential peaks (false discovery rate < 0.05) between AD cases and controls....

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Identifiers

PMID: 30349106
DOI: 10.1038/s41593-018-0253-7

Genes

PSEN1
APP
CR1
GPR22
KMO
MAPT
PIM3
PSEN2
RGCC

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