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Histone H3 Lysine 4 and 27 Trimethylation Landscape of Human Alzheimer’s Disease

19 Feb 2022

Abstract excerpt

BACKGROUND: Epigenetic remodeling is emerging as a critical process for both the onset and progression of Alzheimer's disease (AD), the most common form of neurodegenerative dementia. However, it is not clear to what extent the distribution of histone modifications is involved in AD. METHODS: To investigate histone H3 modifications in AD, we compared the genome-wide distributions of H3K4me3 and H3K27me3 in...

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PMID: 35203383
DOI: 10.3390/cells11040734

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