Article

Epigenomic Aberrations of Histone Methylation in Prefrontal Cortex of Humans with Mild Cognitive Impairment and Alzheimer’s Disease

2025-07-18

Abstract excerpt

Epigenetic mechanisms, particularly histone modifications at gene promoters, are crucial for controlling gene transcription. During the progression of neurodegenerative disorders, epigenomic aberrations may contribute to gene dysregulation, leading to manifestation of symptoms. To test this, we employed a multifaceted approach to investigate how the two key histone methylation marks, H3K4me3 (linked to gene activa...

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Literature Corpus work: 35d2556f-5381-522a-8711-1af077fdcf26
DOI: 10.1101/2025.07.17.25331659

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