Article

scMitoMut for calling mitochondrial lineage–related mutations in single cells

2024-08-06

Abstract excerpt

Tracing cell lineages has become a valuable tool for studying biological processes. Among the available tools for human data, mitochondria DNA (mtDNA) has a high potential due to its ability to be used in conjunction with single-cell chromatin accessibility data, giving access to the cell phenotype. Nonetheless, the existing mutation calling tools are ill-equipped to deal with the polyploid nature of the mtDNA and...

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Literature Corpus work: e9bbfe25-4325-5789-88d6-8d91be784d12
DOI: 10.1101/2024.08.03.606286

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