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Human genetic variation shapes the antibody repertoire across B cell development

2025-05-24

Abstract excerpt

The peripheral antibody repertoire is shaped by inherited genetic variation and selection during B cell development. However, how the repertoire changes across developmental stages and the relative impact of genetics and selection in establishing the antibody repertoire remain largely unknown. To dissect the individual and combined effects of these factors, we integrated antibody repertoire transcriptomics across...

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Literature Corpus work
ed17939a-0237-5cf5-a1b5-36f3a0a20e1f
DOI
10.1101/2025.05.19.654982
Open publication

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Human genetic variation shapes the antibody repertoire across B cell developmentDOI 10.1101/2025.05.19.654982
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