Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire.

Nature communications - 21 Jul 2023

Rodriguez Oscar L, Safonova Yana, Silver Catherine A, Shields Kaitlyn, Gibson William S, Kos Justin T, Tieri David, Ke Hanzhong, Jackson Katherine J L, Boyd Scott D, Smith Melissa L, Marasco Wayne A, Watson Corey T

Abstract excerpt

Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated. Countering models that presume antibodies are generated largely by stochastic processes, we demonstrate that polymorphisms within the immunoglobulin heavy chain locus (IGH) impact the naive and antigen-experienced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to IGH gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Genes, Immunoglobulin Heavy Chain

Share to Germ-Line Mutation

Share to Immunoglobulin Heavy Chains

Share to Monoclonal and Polyclonal Antibodies Research

Share to T-cell and B-cell Immunology

Source

Open in PubMed Open full text

Identifiers

PMID: 37479682
DOI: 10.1038/s41467-023-40070-x
PMCID: PMC10362067

Genes

IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire.PMID 37479682Read ↗

Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoireSemantic proximity Read ↗

Human genetic variation shapes the antibody repertoire across B cell developmentSemantic proximity Read ↗

Germline polymorphisms in the immunoglobulin kappa and lambda loci underpinning antibody light chain repertoire variability.Semantic proximity Read ↗

Germline polymorphisms in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoireSemantic proximity Read ↗

Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoireSemantic proximity Read ↗

Uncovering diversity in the immunoglobulin heavy chain locus.Semantic proximity Read ↗

An integrated human immunoglobulin germline resource linking allele diversity to expressed repertoire structureSemantic proximity Read ↗

The Individual and Population Genetics of Antibody Immunity.Semantic proximity Read ↗

The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease.Semantic proximity Read ↗

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populationsSemantic proximity Read ↗

Large-scale Analysis of 2,152 dataset reveals key features of B cell biology and the antibody repertoireSemantic proximity Read ↗

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.