Article

A Single-Cell Atlas of Transcriptional and Immunoglobulin Repertoire Evolution in Early B Cell Development

2025-10-08

Abstract excerpt

The development of human B cells in the bone marrow can be separated into functionally and transcriptionally distinct subsets, which while canonically described have yet to be profiled deeply and individually and with NGS and bioinformatic techniques. In this study, single-cell RNA sequencing was performed on 65,110 B cells from six healthy donors to observe the foundation of the diversity observed in mature immun...

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Literature Corpus work: 570b78fa-1b4f-5fd0-ac8e-e6b9c40de727
DOI: 10.1101/2025.10.08.681095

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