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Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire

2022-07-04

Abstract excerpt

Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated. Countering models that presume antibodies are generated largely by stochastic processes, we demonstrate that polymorphisms within the immunoglobulin heavy chain locus (IGH) significantly impact the naive and antigen-...

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Literature Corpus work
204761cf-bed3-559b-b396-d4f57b583b99
DOI
10.1101/2022.07.04.498729
Open publication

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Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoireDOI 10.1101/2022.07.04.498729
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