Article

Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire

2025-06-01

Abstract excerpt

Variation in antibody (Ab) responses contributes to variable disease outcomes and therapeutic responsiveness, the determinants of which are incompletely understood. This study demonstrates that polymorphisms in immunoglobulin (IG) light chain loci dictate the composition of the Ab repertoire, establishing fundamental baseline differences that preclude functional Ab-mediated responses. Using long-read genomic seque...

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Literature Corpus work: 8f0c5867-88d5-5c8c-96c6-aa837393c8e2
DOI: 10.1101/2025.05.28.656470

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