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Article

Germline polymorphisms in the immunoglobulin kappa and lambda loci underpinning antibody light chain repertoire variability.

Nature communications - 28 Nov 2025

Engelbrecht Eric, Rodriguez Oscar L, Lees William, Vanwinkle Zach, Shields Kaitlyn, Schultze Steven, Gibson William S, Smith David R, Jana Uddalok, Saha Swati, Peres Ayelet, Yaari Gur, Smith Melissa L, Watson Corey T

Abstract excerpt

Variation in antibody (Ab) responses contributes to variable disease outcomes and therapeutic responsiveness, the determinants of which are incompletely understood. This study demonstrates that polymorphisms in immunoglobulin (IG) light chain loci dictate the composition of the Ab repertoire, establishing fundamental baseline differences that influence functional Ab-mediated responses. Using long-read genomic...

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Share to Antibodies
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin lambda-Chains

Share to Leukocytes, Mononuclear

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Share to Polymorphism, Genetic

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Source

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Identifiers

PMID: 41315391
DOI: 10.1038/s41467-025-66759-9
PMCID: PMC12753720

Genes

IGK
IGL

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