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De novo antibody discovery in human blood from full-length single B cell transcriptomics and matching haplotyped-resolved germline assemblies

2024-03-29

Abstract excerpt

Immunoglobulin (IGH, IGK, IGL) loci in the human genome are highly polymorphic regions that encode the building blocks of the light and heavy chain IG proteins that dimerize to form antibodies. The processes of V(D)J recombination and somatic hypermutation in B cells are responsible for creating an enormous reservoir of highly specific antibodies capable of binding a vast array of possible antigens. However, the a...

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Literature Corpus work
83823f21-1146-5375-8180-c2a177f3cc51
DOI
10.1101/2024.03.26.586834
Open publication

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De novo antibody discovery in human blood from full-length single B cell transcriptomics and matching haplotyped-resolved germline assembliesDOI 10.1101/2024.03.26.586834
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