Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Uncovering diversity in the immunoglobulin heavy chain locus.

Cell genomics - 14 Jan 2026

Hollenbach Jill A

Abstract excerpt

The immunoglobulin heavy chain constant (IGHC) locus houses genetic determinates of antibody function and specificity. In this issue of Cell Genomics, Jana et al. use long-read sequencing to characterize extensive inter-individual diversity in the IGHC region across ancestrally diverse populations, highlighting potential functional consequences.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to Immunoglobulin Heavy Chains

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 41539292
DOI: 10.1016/j.xgen.2025.101134
PMCID: PMC12926211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uncovering diversity in the immunoglobulin heavy chain locus.PMID 41539292Read ↗

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populationsSemantic proximity Read ↗

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations.Semantic proximity Read ↗

Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire.Semantic proximity Read ↗

Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoireSemantic proximity Read ↗

A Novel Framework for Characterizing Genomic Haplotype Diversity in the Human Immunoglobulin Heavy Chain Locus.Semantic proximity Read ↗

An integrated human immunoglobulin germline resource linking allele diversity to expressed repertoire structureSemantic proximity Read ↗

Human genetic variation shapes the antibody repertoire across B cell developmentSemantic proximity Read ↗

Germline polymorphisms in the immunoglobulin kappa and lambda loci underpinning antibody light chain repertoire variability.Semantic proximity Read ↗

Ultra-high-throughput IGH genotyping of 25 global populations reveals population-biased allelic diversity and homozygous V and D gene deletions.Semantic proximity Read ↗

Human IGH germline gene diversity and allele frequencies in 2486 individuals from 25 global populations delineated by ultra-high throughput genotypingSemantic proximity Read ↗

A novel framework for characterizing genomic haplotype diversity in the human immunoglobulin heavy chain locusSemantic proximity Read ↗

Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoireSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.