Article

An integrated human immunoglobulin germline resource linking allele diversity to expressed repertoire structure

2026-06-09

Abstract excerpt

Human immunoglobulin (IG) loci are highly polymorphic, yet existing germline resources remain noisy and incomplete, limiting our ability to link inherited variation to antibody repertoires. Here, we integrate high-fidelity long-read genomic sequencing with matched adaptive immune receptor repertoire sequencing (AIRR-seq) to construct HUSA, a population-scale, evidence-resolved germline resource. Using a conservati...

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Literature Corpus work: c5fe801c-83fc-5141-a969-e21df6d603b5
DOI: 10.64898/2026.06.05.730236

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