Acetylation of histone H2B on lysine 120 regulates BRD4 binding to intergenic enhancers

Abstract excerpt

BRD4 is a bromodomain-containing transcriptional co-regulator that plays important roles in driving transcription by binding to histone acetyl-lysines at enhancers and promoters while recruiting additional transcriptional cofactors. While the mechanisms by which BRD4 regulates transcription have been explored, the critical acetylations primarily responsible for targeting it to chromatin remain unclear. Through a m...

Topics

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• Acylation
• Chromatin Assembly and Disassembly
• Histone Deacetylase Inhibitors Research
• Histones
• Homeostasis
• Lysine
• Oncogene Proteins, Fusion
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

ed13b4ef-536f-5fcc-a532-69067f99a7c8

DOI

10.1101/2025.02.07.637147