Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies

1 Jan 2021

Abstract excerpt

Histone acetylation levels are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) that antagonistically control the overall balance of this post-translational modification. HDAC inhibitors (HDACi) are potent agents that disrupt this balance and are used clinically to treat diseases including cancer. Despite their use, little is known about their effects on chromatin regulators,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors Research
Share to Peptidase Inhibition and Analysis
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33472068
DOI: 10.1016/j.celrep.2020.108638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodiesPMID 33472068Read ↗

The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylationSemantic proximity Read ↗

Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain InhibitorsSemantic proximity Read ↗

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain FamilySemantic proximity Read ↗

JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin statesSemantic proximity Read ↗

Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes.Semantic proximity Read ↗

Bromodomain 4: a cellular Swiss army knifeSemantic proximity Read ↗

Functional Roles of Bromodomain Proteins in CancerSemantic proximity Read ↗

Acetylation of histone H2B on lysine 120 regulates BRD4 binding to intergenic enhancersSemantic proximity Read ↗

Post-Translational Modifications of BRD4: Therapeutic Targets for TumorSemantic proximity Read ↗

Biological function and histone recognition of family IV bromodomain‐containing proteinsSemantic proximity Read ↗

BRD4 in physiology and pathology: ‘‘BET’’ on its partnersSemantic proximity Read ↗

BRD4, Mediator, and Pol II form heterogeneous condensates with distinct transcriptional and acetylation-dependent statesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.