Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.

Nature reviews. Molecular cell biology - 1 Apr 2017

Fujisawa Takao, Filippakopoulos Panagis

Abstract excerpt

Bromodomains (BRDs) are evolutionarily conserved protein-protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues - particularly in histones - and thereby have important roles in the regulation of gene expression. BRD-containing proteins are frequently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acylation
Share to Chromatin Assembly and Disassembly
Share to Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to Lysine

Share to Oncogene Proteins, Fusion

Share to Protein Domains

Share to Protein Processing, Post-Translational

Source

Identifiers

PMID: 28053347
DOI: 10.1038/nrm.2016.143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.PMID 28053347Read ↗

Functional Roles of Bromodomain Proteins in CancerSemantic proximity Read ↗

Bromodomains as therapeutic targets in cancerSemantic proximity Read ↗

Biological function and histone recognition of family IV bromodomain‐containing proteinsSemantic proximity Read ↗

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous ProteinsSemantic proximity Read ↗

The bromodomain: a chromatin browser?Semantic proximity Read ↗

Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain InhibitorsSemantic proximity Read ↗

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous ProteinsSemantic proximity Read ↗

Functional networks of the human bromodomain-containing proteinsSemantic proximity Read ↗

Post-Translational Modifications of BRD4: Therapeutic Targets for TumorSemantic proximity Read ↗

Targeting bromodomain-containing proteins: research advances of drug discoverySemantic proximity Read ↗

Bromodomain 4: a cellular Swiss army knifeSemantic proximity Read ↗

BRD4 in physiology and pathology: ‘‘BET’’ on its partnersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.