Back to search

Article

The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation

2025-05-29

Abstract excerpt

<h4>ABSTRACT</h4> BRD4 regulates gene transcription in complex eukaryotes, in part through the binding of its tandem bromodomains to acetylated lysine residues found in histones and transcription factors. Despite pharmacological inhibition of these domains showing promise in preclinical studies, clinical trial data have been less encouraging so far. A stronger understanding of BRD4 biochemistry could provide a ro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d41f2e5d-a3c4-50dd-aa54-d8142446db24
DOI
10.1101/2025.05.29.656505
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylationDOI 10.1101/2025.05.29.656505
Tandem bromodomains of BRD4 cooperatively read poly-acetylated nucleosomes to enhance chromatin engagement and regulate breast cancer phenotypesSemantic proximity
Nucleosome scaffolding by Brd4 tandem bromodomains in acetylation-dependent chromatin compartmentalizationSemantic proximity
Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain FamilySemantic proximity
Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.Semantic proximity
mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteomeSemantic proximity
Chemical Epigenetics: The Impact of Chemical and Chemical Biology Techniques on Bromodomain Target ValidationSemantic proximity
Bromodomain 4: a cellular Swiss army knifeSemantic proximity
HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodiesSemantic proximity
BRD4 in physiology and pathology: ‘‘BET’’ on its partnersSemantic proximity
JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin statesSemantic proximity
Nucleosome context regulates chromatin reader preferenceSemantic proximity
BRD4 Phosphorylation Regulates the Structure of Chromatin Nanodomains.Semantic proximity
Select a neighboring publication to make it the new centre.