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Biological function and histone recognition of family IV bromodomain‐containing proteins

13 May 2017

Abstract excerpt

Bromodomain proteins function as epigenetic readers that recognize acetylated histone tails to facilitate the transcription of target genes. There are approximately 60 known human bromodomains, which are divided into eight sub-families based on structural conservation. The bromodomain-containing proteins in family IV include seven members (BRPF1, BRPF2, BRPF3, BRD7, BRD9, ATAD2, and ATAD2b). The bromodomains of...

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PMID: 28500727
DOI: 10.1002/jcp.26010

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