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Super-enhancers and the super-enhancer reader BRD4: tumorigenic factors and therapeutic targets

22 Dec 2023

Abstract excerpt

Transcriptional super-enhancers and the BET bromodomain protein BRD4 are emerging as critical drivers of tumorigenesis and therapeutic targets. Characterized by substantial accumulation of histone H3 lysine 27 acetylation (H3K27ac) signals at the loci of cell identity genes and critical oncogenes, super-enhancers are recognized, bound and activated by BRD4, resulting in considerable oncogene over-expression,...

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PMID: 38135679
DOI: 10.1038/s41420-023-01775-6

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