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Article

JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states

2017-11-07

Abstract excerpt

<h4>ABSTRACT</h4> The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BET protein association to histone H4-hyperacetylated chromatin is not understood at the genome-wide level. Here, we report transcription start site (...

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Literature Corpus work
ec64b5e3-1ef1-5460-a1f1-53ecc323b38d
DOI
10.1101/215442
Open publication

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JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin statesDOI 10.1101/215442
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