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Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

1 Mar 2012

Abstract excerpt

Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in the human genome cluster into eight families based on structure/sequence similarity. Here, we present 29 high-resolution crystal structures, covering all BRD families. Comprehensive crossfamily structural analysis identifies conserved...

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PMID: 22464331
DOI: 10.1016/j.cell.2012.02.013

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