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Article

Post-Translational Modifications of BRD4: Therapeutic Targets for Tumor

17 Mar 2022

Abstract excerpt

Bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extraterminal (BET) family, is considered to be a major driver of cancer cell growth and a new target for cancer therapy. Over 30 targeted inhibitors currently in preclinical and clinical trials have significant inhibitory effects on various tumors, including acute myelogenous leukemia (AML), diffuse large B cell lymphoma, prostate cancer,...

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PMID: 35402244
DOI: 10.3389/fonc.2022.847701

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