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Bromodomain 4: a cellular Swiss army knife

22 Jul 2016

Abstract excerpt

Bromodomain protein 4 (BRD4) is a transcriptional and epigenetic regulator that plays a pivotal role in cancer and inflammatory diseases. BRD4 binds and stays associated with chromatin during mitosis, bookmarking early G1 genes and reactivating transcription after mitotic silencing. BRD4 plays an important role in transcription, both as a passive scaffold via its recruitment of vital transcription factors and as...

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PMID: 27450555
DOI: 10.1189/jlb.2ri0616-250r

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