Article

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

2022-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies have identified hundreds of signals for type 2 diabetes (T2D), most of which confer risk through effects on gene expression. We previously identified the transcription factor ZMIZ1 as a probable effector transcript in human islets, but how altered ZMIZ1 expression impacts T2D risk is unknown. We now show that islets from carriers of the T2D-risk alleles have red...

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Literature Corpus work: ece5ffa2-7ca2-5e24-9811-6a72745f12b0
DOI: 10.1101/2022.05.18.492530

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