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Article

The β-Cell Genomic Landscape in T1D: Implications for Disease Pathogenesis

1 Jan 2021

Abstract excerpt

PURPOSE OF REVIEW: Type 1 diabetes (T1D) develops as a consequence of a combination of genetic predisposition and environmental factors. Combined, these events trigger an autoimmune disease that results in progressive loss of pancreatic β cells, leading to insulin deficiency. This article reviews the current knowledge on the genetics of T1D with a specific focus on genetic variation in pancreatic islet regulatory...

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Share to Diabetes and associated disorders
Share to Genetic Associations and Epidemiology
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33387073
DOI: 10.1007/s11892-020-01370-4

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