Article
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.
PLoS genetics - 1 Dec 2015
van de Bunt Martijn, Manning Fox Jocelyn E, Dai Xiaoqing, Barrett Amy, Grey Caleb, Li Lei, Bennett Amanda J, Johnson Paul R, Rajotte Raymond V, Gaulton Kyle J, Dermitzakis Emmanouil T, MacDonald Patrick E, McCarthy Mark I, Gloyn Anna L
Abstract excerpt
The intersection of genome-wide association analyses with physiological and functional data indicates that variants regulating islet gene transcription influence type 2 diabetes (T2D) predisposition and glucose homeostasis. However, the specific genes through which these regulatory variants act remain poorly characterized. We generated expression quantitative trait locus (eQTL) data in 118 human islet samples...
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