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Article

From Genetic Association to Molecular Mechanisms for Islet-cell Dysfunction in Type 2 Diabetes.

Journal of molecular biology - 6 Mar 2020

Mattis Katia K, Gloyn Anna L

Abstract excerpt

Genome-wide association studies (GWAS) have identified over 400 signals robustly associated with risk for type 2 diabetes (T2D). At the vast majority of these loci, the lead single nucleotide polymorphisms (SNPs) reside in noncoding regions of the genome, which hampers biological inference and translation of genetic discoveries into disease mechanisms. The study of these T2D risk variants in normoglycemic...

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Identifiers

PMID: 31945378
DOI: 10.1016/j.jmb.2019.12.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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