Article

Diabetes-associated <i>MYT1</i> and <i>ST18</i> regulate human beta-cell insulin secretion and survival via other diabetes-risk genes

2025-02-25

Abstract excerpt

<h4>Aims/hypothesis</h4> Genetic and environmental factors work together to cause islet beta-cell failure, leading to type 2 diabetes (T2D). How these factors are integrated to regulate beta cells remains largely unclear. Based on our previous findings that the family of Myelin transcription factors (MYT1, MYT1L, and ST18) prevents mouse beta-cell failure by repressing the overactivation of stress response, their...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd03a670-6884-5ea4-ace6-b5df289df7c2
DOI: 10.1101/2025.02.24.639737

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Diabetes-associated <i>MYT1</i> and <i>ST18</i> regulate human beta-cell insulin secretion and survival via other diabetes-risk genesDOI 10.1101/2025.02.24.639737Read

Myt Transcription Factors prevent stress-response gene over-activation to enable postnatal pancreatic β cell proliferation and functionSemantic proximity Read

Metabolic Stress Levels Influence the Ability of Myelin Transcription Factors to Regulate β-Cell Identity and SurvivalSemantic proximity Read

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feedingSemantic proximity Read

Inside the β Cell: Molecular Stress Response Pathways in Diabetes PathogenesisSemantic proximity Read

Mitophagy protects beta cells from inflammatory damage in diabetesSemantic proximity Read

Identification of unique cell type responses in pancreatic islets to stressSemantic proximity Read

Transcriptomic heterogeneity of non-beta islet cells is associated with type 2 diabetes development in mouse modelsSemantic proximity Read

Sex differences in islet stress responses support female beta cell resilienceSemantic proximity Read

Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetesSemantic proximity Read

FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stressSemantic proximity Read

Molecular aspects of pancreatic β‐cell dysfunction: Oxidative stress, microRNA, and long noncoding RNASemantic proximity Read

5’tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetesSemantic proximity Read