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Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets

19 Jan 2023

Abstract excerpt

Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic islets from approximately 300 individuals. We found 395 differentially expressed genes (DEGs) in islets from individuals with T2D, including, to our knowledge, novel (OPRD1, PAX5, TET1) and previously identified (CHL1, GLRA1, IAPP)...

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Diabetes and associated disorders
Pancreatic and Hepatic Oncology Research
Pancreatic function and diabetes

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36656641
DOI: 10.1172/jci163612

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